Active herbicide ingredient Tetflupyrolimet

Active herbicide ingredient Tetflupyrolimet

FMC Corporation and Syngenta commercialize Tetflupyrrolim herbicide technology in Asia to revolutionize weed control in rice.

The new active ingredient Tetflupyrolimet, discovered and developed by FMC with support from Syngenta for the development in rice, marks the first major herbicide with a novel mode of action (DHODH – HRAC Group 28) in over three decades, promising relief to farmers challenged by weed resistance to existing herbicides.

Studies show that this new mode-of-action herbicide provides season-long control of important grass weeds in the rice market, as well as hard-to-control broadleaf weeds and sedges. As disclosed at its Investor Technology Update in November 2020, FMC plans to start the registration process and expects to launch products containing Tetflupyrolimet in the transplanted and direct-seeded rice markets in 2023. The use of Tetflupyrolimet is being tested in other crops, including sugarcane, wheat, soybeans, and corn.

Tetflupyrolimet boosts the yield and quality of rice production by delivering season-long control of the most significant grass weeds, which compete with the crop for water, fertilizer, light, and space, and host pests and diseases that impact rice farming. A further benefit of this technology is that it can be used at low rates with good crop safety. In addition to being easy to apply in traditional transplanted rice, the herbicide is also highly suited to direct-seeded rice, paving the way for the greater adoption of modern and more environmentally friendly cropping systems.

Syngenta and FMC will both bring Tetflupyrolimet-based products to key rice markets in Asia. Syngenta will register and commercialize Tetflupyrolimet in China – the world’s largest rice market. In addition, Syngenta will commercialize products containing mixtures of Tetflupyrolimet for rice in India, Vietnam, and Indonesia, as well as in Japan and South Korea. FMC will register and commercialize Tetflupyrolimet and an array of products in all these countries, except in China where it will focus on mixtures for rice. Syngenta will further exclusively commercialize Tetflupyrolimet for rice in Bangladesh.


Description: Tetflupyrolimet is an N-alkyl pyrrolidine that is pyrrolidine substituted by methyl, oxo, (2-fluorophenyl)aminocarbonyl, and 3-(trifluoromethyl)phenyl groups at positions 1, 2, 3, and 4, respectively. It is a herbicide developed by FMC Corporation for the control of grass weeds in rice, as well as broadleaf weeds and sedges. It has a role as a herbicide, a pyrimidine synthesis inhibitor, and an EC [dihydroorotate dehydrogenase (quinone)] inhibitor. It is an anilide, a member of monofluorobenzenes, a secondary carboxamide, a member of (trifluoromethyl)benzenes, an N-alkyl pyrrolidine and a pyrrolidine carboxamide.

Pesticide type: Herbicide

Pests controlled: Grass weeds including ryegrass, barnyard grass, some sedges, and broadleaf weeds.

Applications: Rice, Sugarcane, Citrus.

IUPAC: 3-Pyrrolidinecarboxamit, N-(2-fluorophenyl)-1-metyl-2-oxo-4-[3-(triflometyl)phenyl]-, (3S, 4S)-

CAS No.: 2053901-33-8

Substance groups: Anilide herbicide.

Chemical formula: C19H16F4N2O2

Mode of action: It stimulates RNA synthesis, and is absorbed through stems and roots. It has no herbicidal activity but is rapidly hydrolyzed to active metabolites.

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